Evaluation of genotoxicity in leukocytes and testis following intra-vasal contraception with RISUG and its reversal by DMSO and NaHCO3 in Wistar albino rats
Evaluation of genotoxicity of RISUG®–a vas based contraceptive, was carried out in the
present study. Animals were allotted into groups of sham operated control, vas occlusion
with RISUG (5–7μl) for 360 days and reversal by DMSO (250–500μl) and 5% NaHCO3
(500μl). Blood samples and testis were collected at 360 days of vas occlusion and 90 days
of vas occlusion reversal for comet analysis. Hydrogen peroxide induced samples were
used as positive control. Olive moment, tail length and percentage DNA in tail were recorded …
present study. Animals were allotted into groups of sham operated control, vas occlusion
with RISUG (5–7μl) for 360 days and reversal by DMSO (250–500μl) and 5% NaHCO3
(500μl). Blood samples and testis were collected at 360 days of vas occlusion and 90 days
of vas occlusion reversal for comet analysis. Hydrogen peroxide induced samples were
used as positive control. Olive moment, tail length and percentage DNA in tail were recorded …